Chemical research in toxicologyAnimalsHumansChemical and Drug Induced Liver InjuryDrug IndustryLongitudinal Studies
Industry Perspective on Nonclinical Approaches for Hepatotoxicity Risk Assessment: Insights from Two Longitudinal Surveys Conducted in 2023 and 2017.
Melanie Z Sakatis, Leah M Norona, Jamie E Karmel, William R Proctor, Fatou H Sarr, Payal Rana, Doris Zane, Jessica Caverly Rae, Samantha C Faber, Ravindra C Kodihalli, Arie Regev, Debra Luffer-Atlas, Onyi Irrechukwu, David H Alpers, Jonathan P Jackson
Published: 202510.1021/acs.chemrestox.5c00235
Abstract
The Nonclinical Translation Working Group of the IQ Drug-Induced Liver Injury (DILI) Consortium conducted two surveys in 2023 and 2017 to canvas member companies on approaches and experiences in the preceding 5-year periods that inform how DILI risk…
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