Chemical research in toxicologyPiperazinesPhthalazinesMolecular Docking SimulationHumansQuantum Theory
Olaparib Metabolism: Quantum Chemistry, Docking, and Dynamics-Based Insights into Mechanisms and Reactivity.
Anila Nuthi, Upadhyayula Suryanarayana Murty, Vaibhav A Dixit
Published: 202510.1021/acs.chemrestox.5c00212
Abstract
Olaparib, an anticancer drug, has been recently associated with major side effects (hepatotoxicity and hematotoxicity). Human CYP450 3A4/5 metabolizes olaparib and forms dehydrogenated (M11) and hydroxylated (M6, M15) metabolites. The major (dehydrog…
Preview only. Read the full abstract at the source