Cationic Poly(glucosamine)-Based Polymers Bind to Glycans with Varying Affinity Facilitating Transport across the Glycocalyx of Endothelial Cells.

Natural polysaccharides, such as chitosan, offer promising avenues for drug delivery due to their cytocompatibility and ability to interact with cell surfaces. However, the endothelial glycocalyx, a glycan-rich extracellular matrix, presents a barrie…

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