BiomacromoleculesMembrane ProteinsHydrophobic and Hydrophilic InteractionsHumansPolyethyleneimineInterferon-beta
Simple Hydrophobic Modification of bPEI Confers Potent, STING-Dependent Innate Immunostimulatory Activity.
Aolin Sun, Liping Liu, Zichao Huang, Yaxin Zhang, Zhenyi Zhu, Jiangai Long, Ziyue An, Yibo Wang, Yusong Cao, Dianwei Wang, Wantong Song
Published: 202610.1021/acs.biomac.5c01869
Abstract
Macromolecular agonists are promising immunomodulators due to multivalency and tunable architectures. Previously, we showed that branched polyethylenimine (bPEI) conjugated with nitrogen-containing heterocycles activates the STING pathway, with branc…
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