BiomacromoleculesCHO CellsAnimalsCricetulusRecombinant ProteinsEndoplasmic Reticulum Chaperone BiP
Genetic Factors Affecting the Quality of Recombinant Therapeutic Proteins in CHO Cells.
Chun-Liu Mi, Shao-Lei Geng, Jing-Wen Xue, Qiu-Li Sun, Wei-Hua Dong, Ji-Hong Zhang, Qin Li, Xiao-Yin Wang, Tian-Yun Wang
Published: 202610.1021/acs.biomac.5c01454
Abstract
Recombinant therapeutic proteins (RTPs) are widely used to treat various major diseases. Chinese hamster ovary (CHO) cells are the preferred mammalian cell expression system for the production of RTPs. However, maintaining high productivity while ens…
Preview only. Read the full abstract at the source