BiomacromoleculesRNAMessengerAnimalsHumansPolyamines
Polyamine-Modified Poly(aspartic acid) for mRNA Delivery with In Vivo Lung-Targeted Ability.
Yuyan Zhang, Pingjie Sun, Sheng Ma, Zhaopei Guo, Hanqin Zhao, Yibo Qi, Minhui Li, Wantong Song, Zhaohui Tang
Published: 202510.1021/acs.biomac.5c00802
Abstract
Polymers are widely used as mRNA delivery platforms, but their clinical translation is limited by challenges such as nonorgan-selective expression and low in vivo efficacy. Poly(amino acids), particularly poly(aspartic acid) (PAsp), have been extensi…
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