BiomacromoleculesHydrogelsElastinTemperaturePeptidesProtein Multimerization
Building Thermosensitive Single-Component Protein Hydrogels from De Novo Designed Homodimers.
Jianglan Ning, Lurong Zhang, Yaxin Wang, Fenghui Guan, Sheng Ye
Published: 202510.1021/acs.biomac.5c00691
Abstract
Leveraging recent advances in protein design, we explored de novo designed proteins as building blocks for hydrogels. Specifically, we investigated two homodimers, a highly stable β-barrel dimer and a helical dimer. By incorporating elastin-like poly…
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