Bioconjugate chemistry
Dynamic Light Scattering for Assessing Aggregation in [177Lu]Lu-DOTA-Trastuzumab: A Quality Control Approach for Radioimmunotherapy.
Huu Bao Nguyen, Aran Kim, Muhammad Zeeshan, Thuy Tien Nguyen, Gyeong-Tak Byeon, Jeong Eun Lim, Min-Kyoung Kang, Kanghyuk Choi, Jeongsoo Yoo
Published: 202610.1021/acs.bioconjchem.5c00651
Abstract
Radioimmunotherapy (RIT) delivers radionuclides to tumors through antibody-based targeting. However, radiolabeling with high-linear energy transfer (LET) isotopes like Lu-177 can induce aggregation, reducing antibody stability and bioactivity. In thi…
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