Bioconjugate chemistry
Unsaturated Fatty Acid-Conjugated Amonafide Fluorescent Prodrugs for Autophagy Disruption and Cancer Theranostics.
Wenwei Sun, Lixian Fu, Zhuoying Chen, Ling Li, Fangju Chen, Bo Zhang, Xiangjie Luo, Yong Qian
Published: 202610.1021/acs.bioconjchem.5c00604
Abstract
Despite the powerful antitumor activity of amonafide (ANF), its use in the clinic has been limited by dose-dependent toxicities. To address this challenge, we developed a series of unsaturated fatty acid-amonafide conjugates, leveraging the biocompat…
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