Bioconjugate chemistryLeukocyte ElastaseHumansAnimalsImmunoconjugatesOligopeptides
Utilization of Neutrophil Elastase Tetrapeptide Substrate as a Linker Agent for Anti-GD2 Antibody Drug Conjugates.
Lingli Gao, Hanrui Wei, Junyi Zhang, Yijia Zheng, Jiajia Zhang, Yanbo Zheng, Jigang Yang, Jianhua Gong
Published: 202610.1021/acs.bioconjchem.5c00590
Abstract
Disialoganglioside GD2 (GD2) is highly expressed in several tumors. While anti-GD2 antibodies and GD2-based antibody-drug conjugates (ADCs) have shown some therapeutic efficacy, their activity requires enhancement. Elastase, abundant in tumor microen…
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