Bioconjugate chemistry
Fluorogenic Imaging Enables the Identification of Phosphoramidate Antibody-Drug Conjugate Linkers.
Pradeep Shrestha, Veera V Shivaji R Edupuganti, Connor Wang, Nimit L Patel, Lai Thang, Simone Difilippantonio, Martin J Schnermann
Published: 202610.1021/acs.bioconjchem.5c00578
Abstract
Modular, tunable linker chemistries that are stable in circulation yet selectively cleaved are needed to realize the therapeutic potential of antibody-drug conjugates (ADCs). Near-infrared (NIR) fluorogenic imaging using norcyanine carbamate (CyBam)…
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