Bioconjugate chemistry
An Engineered Fc with a Single Glycosylation Site Enables the Precise Conjugation of an Antibody with One Payload.
Fengnan Song, Yan Zhao, Yaqi Shi, Hanxu Xu, Xiangman Zou, Zhi Liu, Xintong Liu, Shuchang Ning, Holger Husi, Wei Shi, Feng Tang, Wei Huang, Weihua Meng
Published: 202610.1021/acs.bioconjchem.5c00539
Abstract
Although ADCs have demonstrated great potential in tumor treatment, acquired resistance to ADCs has been reported, related to both the targets and the payloads. One strategy is to increase the diversity of the payloads. The cytotoxicity and other inh…
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