Bioconjugate chemistryHumansAnimalsHepatitis A Virus Cellular Receptor 2MiceGallium Radioisotopes
Targeting T-Cell Immunoglobulin and Mucin Domain 3 with a D-Configured Peptide Radiotracer for Tumor Positron Emission Tomography Imaging.
Jiawen Huang, Jiale Xie, Junyu Bao, Kezhi Ding, Yuting Dai, Xiaochuan Zha, Chuan Chen, Wenhao Liu, Zonghua Luo
Published: 202510.1021/acs.bioconjchem.5c00504
Abstract
T-cell immunoglobulin and mucin domain 3 (TIM-3), a critical immunosuppressive checkpoint receptor, regulates antitumor immunity within the tumor microenvironment (TME). Noninvasive quantification of TIM-3 expression could be helpful for guiding immu…
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