Bioconjugate chemistryAnimalsCarbonGlutathionePeryleneMice
Perylene Tetracarboxylic Dianhydride Carbon Dots Deplete Glutathione to Induce Immunogenic Cell Death in Tumor Cells.
Yueqi Tang, Yuting Lu, Bo Yu, Hui Zhang, Guanghuao Li, Minghao Sun, Xiaodan Wu, Yimeng Sun, Guanghui Tan, Yingxue Jin
Published: 202510.1021/acs.bioconjchem.5c00441
Abstract
High glutathione levels in the tumor microenvironment drive tumor resistance and proliferation, making glutathione depletion a key cancer therapeutic strategy. Existing inhibitors face issues such as poor specificity and biocompatibility, creating a…
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