Bioconjugate chemistryBlood-Brain BarrierTranscytosisHumansAnimalsReceptors
Antibody Engineering for Receptor-Mediated Transcytosis Across the Blood-Brain Barrier.
Kaiyuan Guo, Dinglingge Cao, Lucia P Marchese-Thomas, Yizhou Dong
Published: 202510.1021/acs.bioconjchem.5c00379
Abstract
Efficient delivery of therapeutic antibodies into the central nervous system (CNS) remains severely limited by the restrictive nature of the blood-brain barrier (BBB). Receptor-mediated transcytosis (RMT) has emerged as a promising strategy to enhanc…
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