Bioconjugate chemistryAnimalsNanoparticlesHumansMicePolylactic Acid-Polyglycolic Acid Copolymer
Comprehensive Evaluation of Human and Murine Protein Coronae Formed on Choline Carboxylic Acid Ionic Liquid-Modified PLGA Nanoparticles.
Claylee M Chism, Bakhtyar Sepehri, Nicole Guerin, Rebekah Heintz, Christine M Hamadani, Anh Hoang, Anter A Shami, Mary Beth Vanlandingham, Gaya Dasanayake, Ethan Jarrett, Sandeep K Misra, Robert J Doerksen, Joshua S Sharp, Xiuquan Wang, Eden E L Tanner
Published: 202510.1021/acs.bioconjchem.5c00347
Abstract
Despite decades of research, the successful clinical translation of intravenously administered nanomedicines is underwhelming. One significant barrier to progress is the opsonization and rapid clearance from the bloodstream due to protein corona form…
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