Biochemistry
Systematic Application of a Cellular Thermal Shift Assay for Inferring Inhibitor Binding Affinity to 17βHSD13 in a Humanized Liver Homogenate.
Sandra Lunnerdal, Fredrik Wågberg, Göran Dahl, Andrea Ahnmark, Pia Hansson, Ella Sampers, Katja Madeyski-Bengtson, William Lee, Lars Löfgren, Bader Zarrouki, Stefan Hallén, Thomas Lundbäck
Published: 202610.1021/acs.biochem.5c00697
Abstract
Human loss-of-function variants in 17βHSD13 have been associated with reduced risk and progression of metabolic and alcohol-related liver disease. Although in vitro experiments implicate 17βHSD13 in the processing of steroidal and lipogenic substrate…
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