BiochemistryBoronic AcidsRacemases and EpimerasesEnzyme InhibitorsStructure-Activity RelationshipBinding Sites
Inhibition of Mandelate Racemase by Boron-Based Inhibitors: Different Binding Modes for Benzoxaboroles Versus Boronic Acids.
Joshua A Hayden, Anika Jabin, Oliver P Kuehm, Julia G Moncrief, Martin St Maurice, Stephen L Bearne
Published: 202610.1021/acs.biochem.5c00655
Abstract
Mandelate racemase (MR) catalyzes the Mg2+-dependent interconversion of (R)- and (S)-mandelate and has been employed as a model enzyme to demonstrate that an enzyme catalyzing the deprotonation of a carbon acid substrate may be inhibited by boronic a…
Preview only. Read the full abstract at the source