Biochemistry
The S180R Human Germline Variant of DNA Polymerase β Is a Low Fidelity Enzyme with Reduced Flexibility of the Fingers Domain.
Danielle L Sawyer, Brian E Eckenroth, Cristian Chavira, Khadijeh Alnajjar, John P Hanley, Julie A Dragon, Sylvie Doublié, Joann B Sweasy
Published: 202610.1021/acs.biochem.5c00628
Abstract
DNA polymerase β (Pol β) is an important polymerase that functions in DNA repair within the Base Excision Repair and Non-Homologous End-Joining pathways. It is estimated to function in the repair of up to 50,000 DNA lesions per cell per day, within t…
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