Biochemistry
Cyclized Peptide Inhibitors of the Small G Protein Cdc42 Mimic Binding of Effector Proteins.
Natasha P Murphy, George J N Tetley, Jefferson Revell, Helen R Mott, Darerca Owen
Published: 202610.1021/acs.biochem.5c00616
Abstract
The Ras superfamily of small GTPases are challenging targets for therapeutic inhibition, partially due to a lack of pockets amenable to small molecule inhibition. Our previous work identified high-affinity cyclized peptide binders of Cdc42, a member…
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