Analytical chemistryBiosensing TechniquesCRISPR-Cas SystemsSite-Specific DNA-Methyltransferase (Adenine-Specific)Limit of DetectionHumans
Customizable NAND Logic-Gate Biosensing System Enabled by an Engineered Methylation-CRISPR/Cas12a Consensus Sequence for Ultrasensitive DNA Methyltransferase Detection.
Jia Zhao, Zhuqi Sui, Baoqiang Chen, Rongrong Wu, Jianguo Xu, Haiyan Dong
Published: 202610.1021/acs.analchem.5c06772
Abstract
DNA methyltransferases (MTases) play crucial roles in epigenetic regulation, and their abnormal activity is closely associated with various human diseases. Here, we report a customizable NAND logic-gate biosensing platform for highly sensitive and in…
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