Deep-Coverage Ubiquitylomics with Low Starting Materials Reveals Dysregulation of Ubiquitinated FASN as a Key Regulator of MAFLD Pathogenesis.

Metabolic-associated fatty liver disease (MAFLD), characterized by excessive hepatic lipid deposition, poses a global health threat, increasing the risk of severe liver complications. Here, we optimized a fast in-tube microscale ubiquitylomics strate…

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