Analytical chemistryAldehydesBiomarkersHumansIsotope LabelingDiabetes Mellitus
Development of a Novel Hydroxylamine-Based Stable Isotope Labeling Reagent for Profiling Aldehyde Metabolic Biomarkers in Diabetes Using LC-MS/MS and Machine Learning.
Chuanyuan Du, Yuxin Zhang, Wenjie Zhu, Xiang Liu, Nian Liu, Zhenyu He, Junling Liu, Yawei Lin, Xiaosong Hu
Published: 202510.1021/acs.analchem.5c04501
Abstract
Aldehyde compounds are significantly associated with diabetes mellitus. The metabolic profile of aldehydes can enhance understanding of the mechanisms underlying development of diabetes. This study employed a pair of stable isotope labeling (SIL) rea…
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