Analytical chemistryAmyloid beta-PeptidesPeptide FragmentsMolecular Dynamics SimulationNuclear Magnetic ResonanceBiomolecular
Discrimination of Formation Processes of Amyloid β Fibrils with Distinct Morphologies Using Rheo-NMR Spectroscopy.
Daichi Morimoto, Erik Walinda, Soki Shimizu, Jana Farré, Masahiro Shirakawa
Published: 202510.1021/acs.analchem.5c04379
Abstract
The accumulation of abnormal protein fibrillar aggregates is a hallmark of various neurodegenerative diseases. Notably, a single type of protein species can form fibrils with distinct morphologies, and recent studies have linked fibril polymorphism t…
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