Analytical chemistryPolynucleotide 5'-Hydroxyl-KinaseHumansDNABiocatalysisHeLa Cells
Amplified Intracellular Imaging of Polynucleotide Kinase via a Self-Stacking Autocatalytic DNA Circuit.
Zhaolin Wang, Sini Li, Ying Deng, Ruomeng Li, Xiaoqing Liu, Fuan Wang
Published: 202510.1021/acs.analchem.5c03752
Abstract
Polynucleotide kinase (PNK) plays a pivotal role in nucleic acid metabolism and is closely associated with genome instability and disease progression. However, current PNK detection methods are constrained by the low sensitivity and complex probe com…
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