Analytical chemistryProto-Oncogene Proteins p21(ras)HumansTandem Mass SpectrometryParaffin EmbeddingFormaldehyde
Quantitative Assessment of the Target Engagement of a KRAS G12C Inhibitor in Formalin-Fixed Paraffin-Embedded Tumor Tissues Using Immunoaffinity Capture 2D-LC-MS/MS.
Aiying Yu, Jintang He, Lingyao Meng, Zhen Shi, Emily Chan, Jian Jiang, Mark Merchant, Surinder Kaur, Keyang Xu
Published: 202510.1021/acs.analchem.5c02696
Abstract
Understanding the target engagement of covalent inhibitors, such as KRAS G12C inhibitors, is essential for evaluating their mechanisms of action and efficacy, particularly given the KRAS G12C mutation's significant role in cancer progression. We prev…
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