Analytical chemistryDNASurface Plasmon ResonanceEnzyme-Linked Immunosorbent AssayProtein BindingDNA-Binding Proteins
A Modular Protein-DNA Multimer Model to Explore How Valence and Monomer Affinity Shape Multivalent DNA Binding.
Hyoin Park, Yongwon Jung
Published: 202510.1021/acs.analchem.5c02695
Abstract
Multivalent interactions enhance binding strength through the cooperative effects of multiple weak interactions. While multivalency is known to improve sensitivity, increased valency can also enhance nonspecific interactions, potentially compromising…
Preview only. Read the full abstract at the source