Accounts of chemical researchNanoparticlesRNAMessengerEndosomesLipids
Ionizable Lipid Nanoparticles for mRNA Delivery: Internal Self-Assembled Inverse Mesophase Structure and Endosomal Escape.
Haitao Yu, Brendan P Dyett, Calum J Drummond, Jiali Zhai
Published: 202510.1021/acs.accounts.5c00522
Abstract
ConspectusThe clinical use of mRNA COVID-19 vaccines developed by Moderna and Pfizer-BioNTech has highlighted the critical role of ionizable lipid nanoparticles (LNPs) in the efficient loading, intracellular delivery, and cytoplasmic release of mRNAs…
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