Accounts of chemical researchHumansProtein Kinase InhibitorsDrug ResistanceNeoplasmDrug Discovery
Chemical Adaptation in Drug Discovery: The Medicinal Chemistry Journey of Olverembatinib and Limertinib in Overcoming Kinase Drug Resistance.
Ke Ding, Yupeng Li, Yang Zhou, Weixue Huang
Published: 202510.1021/acs.accounts.5c00496
Abstract
ConspectusDrug resistance remains one of the biggest challenges in kinase inhibitor therapy, particularly in cancers where prolonged treatment fosters the emergence of resistant mutations. These mutations often alter amino acid residues within the ki…
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