Introduction of methicillin-resistant Staphylococcus aureus (MRSA) nasal polymerase chain reaction testing combined with pharmacist ordering and intervention reduces anti-MRSA antibiotic use in a multi-hospital system.

Methicillin-resistant Staphylococcus aureus (MRSA) nasal polymerase chain reaction implementation combined with pharmacist oversight across four hospitals resulted in a 20.2% reduction in anti-MRSA agent standardized antimicrobial administration ratios with significant reductions across 17 of 23 patient care units, further supporting this approach as an effective, multi-center, antimicrobial stewardship strategy.