Regulatory toxicology and pharmacology : RTPAnimalsFertilityRetrospective StudiesFemaleMale
Retrospective evaluation of the use of non-human primates for fertility assessment of pharmaceuticals submitted for marketing approval in the EU.
Puck Roos, Diann L Blanset, Peter Jk van Meer, Shermaine Mitchell-Ryan, Peter T Theunissen, Katie J Turner, Ronald L Wange, Christopher J Bowman
Published: 202610.1016/j.yrtph.2025.105967
Abstract
During development, potential adverse effects of pharmaceuticals on male and female fertility are evaluated. Although non-human primates (NHP) can be an appropriate model for some pharmaceuticals, there are scientific, ethical and practical limitatio…
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