Molecular therapy : the journal of the American Society of Gene Therapy
ALCAT1 Promotes Diabetic Cardiomyopathy by Linking Myocardial Tetralinoleoyl Cardiolipin Deficiency to Lipotoxicity.
Dandan Jia, Yuguang Shi
Published: 202610.1016/j.ymthe.2026.01.025
Abstract
Cardiolipin (CL) is a mitochondria-specific phospholipid essential for maintaining cardiac bioenergetic function. In diabetes, the depletion of tetralinoleoyl cardiolipin (TLCL)-the predominant CL species in healthy myocardium-has been implicated in…
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