Molecular therapy : the journal of the American Society of Gene Therapy
JMJD3 and UTX as Key Targets for Gene-Modified Mesenchymal Stem Cell Therapy in Cartilage Tissue Engineering.
Lyess Allas, Juliette Aury-Landas, Quitterie Rochoux-Briet, Anais Julien, Eva Lhuissier, Marion Lente, Sybille Brochard, Alexis Veyssiere, Karim Boumédiene, Catherine Baugé
Published: 202610.1016/j.ymthe.2026.01.018
Abstract
Histone methylation plays a critical role in cartilage development, making it an appealing target for improving cartilage engineering protocols. In this study, we evaluated the roles of JMJD3 (KDM6B) and UTX (KDM6A), both demethylases of histone H3 a…
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