Molecular therapy : the journal of the American Society of Gene Therapy
Clinical trial results provide the rationale to protect dual HIV-specific T cells with a signaling-defective HIV fusion inhibitor.
Pablo Tebas, Julie K Jadlowsky, Yuqi Zhou, M Betina Pampena, George J Leslie, Nan Liu, Sriram Srivatsa, Colby R Maldini, Jingxin Wang, Chungdhak Jaming Tsang, Ola Mohamed, Josephine Romano, Beth Haggarty, Gabriela Plesa, Avery L Gaymon
Published: 202610.1016/j.ymthe.2026.01.006
Abstract
Coupling the HIV fusion inhibitor C34 with CXCR4 (C34-CXCR4) protected CD4 T cells from all strains of HIV. Escape from C34-CXCR4 expression proved difficult, requiring more than 21 serial passages, mutations at conserved gp41 sites, and a complete l…
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