Molecular therapy : the journal of the American Society of Gene Therapy
A CD40-OX40 co-stimulatory circuit orchestrates protective CD4+ T cell immunity in tuberculosis.
Ximeng Zhang, Jing Yang, Fuxiang Li, Yu Wang, Zhaodong Li, Wenfei Wang, Yunlong Hu, Chenyan Shi, Fan Pan, Carl G Feng, Yejun Wang, Qianting Yang, Xinchun Chen, Yi Cai
Published: 202610.1016/j.ymthe.2025.12.062
Abstract
Effective CD4+ T cell responses are essential for controlling Mycobacterium tuberculosis (Mtb), but they fail to achieve sterilizing immunity in infected lungs. In mouse models of Mtb infection, single-cell transcriptomic profiling identified a domin…
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