Molecular therapy : the journal of the American Society of Gene Therapy
A synthetic hyperglycemia-sensing gene circuit enhances blood glucose homeostasis in diabetic mice.
Yuan Zhang, Shuai Deng, Yanlun Zhu, Xu Li, Jiani Deng, Chengdong Wang, Jianmin Sun, Feixiang Bao, Shibing Tang, Haifeng Ye, Hon Fai Chan, Hui Zhao
Published: 202610.1016/j.ymthe.2025.12.059
Abstract
Synthetic gene circuits can be programmed to produce therapeutic proteins in response to the presence of disease biomarkers. Here, we established a hyperglycemia-sensing gene circuit to enhance blood glucose homeostasis in diabetic mouse models. To a…
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