Molecular therapy : the journal of the American Society of Gene Therapy
Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β pathway.
Zhongxiao Lin, Jianyu Xiong, Fuyuan Zhang, Hao Zhang, Menglin Zhu, Caiyu Li, Rong Fu, Zhongyi Zhang, Qinwen Hu, Jie Liang, Bohan Fu, Chiyuan Ma, Kehan Jin, Liuyi Lu, Junmeng Zheng
Published: 202510.1016/j.ymthe.2025.12.035
Abstract
Vascular senescence is a fundamental driver of age-related cardiovascular diseases, yet the epigenetic mechanisms controlling this process remain poorly understood. This study investigated the role and underlying mechanisms of lysine acetyltransferas…
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