Molecular therapy : the journal of the American Society of Gene Therapy
Bispecific BAFF-R/BCMA CAR T cells control growth of heterogeneous plasma cells in multiple myeloma.
Agnese Fiori, Karin Zimmermann, Anna Li, Jörg Westermann, Ioannis Anagnostopoulos, Lutz Menzel, Mario Bunse, Henry Erdlei, Jeyan Jayarajan, Florian Grünschläger, Juan Pablo Ortiz-Aguirre, Simon Haas, Uwe-Jens Teßmann, Jens Freitag, Andreas Rosenwald
Published: 202510.1016/j.ymthe.2025.12.005
Abstract
Multiple myeloma treatment has experienced tremendous advances through chimeric antigen receptor (CAR) therapies directed to the B cell maturation antigen (BCMA), but remissions are usually transient. To mitigate the risk of BCMA immune escape, we ai…
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