Molecular therapy : the journal of the American Society of Gene Therapy
Innate immune-cell-derived BAFF promotes inflammatory response of ICOSL⁺ B cells via non-canonical NF-κB in diabetic autoimmunity.
Zeying Li, Mingjiu Zhao, Wenjun Luo, Xin Liang, Xinyu Li, Teri Hatzihristidis, Kehua Guo, Xia Li, Yang Xiao, Qiaolin Deng, Paul Love, Jiaqi Huang, Bin Zhao, Zhiguang Zhou
Published: 202510.1016/j.ymthe.2025.12.003
Abstract
Type 1 diabetes (T1D) is an autoimmune disease resulting from the failure of the immune system to maintain self-tolerance, leading to autoimmune destruction of pancreatic β cells. Although T1D has traditionally been considered as a T cell-driven dise…
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