Molecular therapy : the journal of the American Society of Gene Therapy
Targeting renal tubular WWP2 to restore mitochondrial OXPHOS integrity retards the AKI-to-CKD transition.
Mengqiu Wu, Mengqiu Miao, Yuting Li, Jiaojiao Fan, Wenping Zhu, Yujia Niu, Ruotian Liu, Weiyi Chen, Ran Zou, Songming Huang, Yue Zhang, Mi Bai, Ran You, Zhanjun Jia, Aihua Zhang
Published: 202510.1016/j.ymthe.2025.11.022
Abstract
Defects in mitochondrial energy metabolism in injured tubular epithelial cells (TECs) are a well-recognized hallmark of kidney injury pathogenesis; however, the key target leading to this defect during the acute kidney injury (AKI)-to-chronic kidney…
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