Molecular therapy : the journal of the American Society of Gene Therapy
Development of a high-affinity anti-ROR1 variable region for broad anti-cancer immunotherapy.
Joshua K M Wong, Pui Yeng Lam, Elaina Coleborn, Jiya Jose, Louisa Alim, Cui Tu, Magdalena Antczak, Bettina Dietmair, Arghavan Golbaz Hagh, Lucia Noronha, Seth W Cheetham, John Hooper, Paul A Beavis, Delphine Merino, Jean Berthelet
Published: 202510.1016/j.ymthe.2025.11.021
Abstract
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an emerging target in cancer immunotherapy, recognized for its consistent and elevated expression across several epithelial tumors, including triple-negative breast cancer (TNBC). TNBC is an a…
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