Molecular therapy : the journal of the American Society of Gene Therapy
Mesenchymal stromal cells engineered with ACE2 for treatment of receptor-mediated viral lung injury.
Yuchong Li, Jady Liang, Zhanwen Zhang, Ori Rotstein, Masaki Nakane, Leanne Wybenga-Groot, Julie Khang, Aye Aye Khine, Yonghao Xu, Yimin Li, Beverley A Orser, John G Laffey, Michael Matthay, Arthur S Slutsky, Samira Mubareka
Published: 202510.1016/j.ymthe.2025.11.020
Abstract
Acute respiratory distress syndrome (ARDS) is a major cause of mortality in severe viral pneumonia, including COVID-19. Current antivirals reduce viral replication but fail to address the dysregulated host inflammation that drives lung failure, while…
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