Molecular therapy : the journal of the American Society of Gene Therapy
METTL5 promotes fatty acid metabolism by modulating peroxisome to induce hepatocellular carcinoma recurrence after thermal ablation.
Zonglin Xie, Lina Wang, Yifan Wu, Yifan Zhang, Shuo Wang, Xuezhen Zeng, Ruiming Liang, Jianting Long, Jianping Guo, Sui Peng, Ming Kuang, Shuibin Lin, Zihao Dai, Shuling Chen
Published: 202510.1016/j.ymthe.2025.11.016
Abstract
Thermal ablation (TA) (e.g., radiofrequency ablation [RFA]) is a critical curative therapy for hepatocellular carcinoma (HCC). However, the high recurrence rate of HCC after ablation remains a major clinical challenge. Hyperactive mRNA translation me…
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