Molecular therapy : the journal of the American Society of Gene TherapyMacrophagesAnimalsDiabetic NephropathiesProtein-Arginine Deiminase Type 4Humans
PAD4 promotes macrophage migration to aggravate tubulointerstitial injury in diabetic kidney disease.
Yunjie Xiong, Ruolin Li, Xiangjun Chen, Chuan Peng, Qinglian Zeng, Shuangshuang Zhu, Furong He, Jinshan Wu, Jiangyun Lei, Miaoyun Chen, Shiyun Tong, Yue Sun, Yong Xu, Wei Huang, Shumin Yang
Published: 202610.1016/j.ymthe.2025.10.009
Abstract
Peptidyl arginine deiminase 4 (PAD4) is an enzyme predominantly expressed in myeloid cells, and its role in diabetic kidney disease (DKD) remains unknown. We functionally characterized 48 PADI4 variants identified among 469,779 participants from UK B…
Preview only. Read the full abstract at the source