Molecular genetics and metabolism
Multi-omics analysis reveals ER stress as a main feature in two endothelial cell models of N-linked congenital disorders of glycosylation.
Karen Driesen, Veronika Holubová, Pedro Magalhães, Shauni Loopmans, Mainak Guharoy, Isabelle Meyts, Eva Morava, Bart Ghesquière, Peter Witters
Published: 202610.1016/j.ymgme.2026.109737
Abstract
Glycosylation is one of the most important posttranslational modifications. When the glycosylation machinery is affected, this leads to a congenital disorder of glycosylation (CDG). CDG are a class of rare multisystemic diseases that often affect the…
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