Metabolic engineering
An automated platform for accelerating and focusing adaptive laboratory evolution.
Peter Ruppen, Maximilian Ole Bahls, Michael Sebastian Gerlt, Martin Peter Edelmann, Tania Michelle Roberts, Philippe Marlière, Sven Panke
Published: 202510.1016/j.ymben.2025.12.007
Abstract
The rate of change in adaptive laboratory evolution (ALE), in which a population of microorganisms is continuously cultivated under a specific selective pressure, is controlled by the cellular mutagenesis rate and the randomness of where in the genet…
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