Metabolic engineering
Lacto-N-tetraose biosynthesis from lactose via metabolically rewired Escherichia coli.
Dileep Sai Kumar Palur, Shannon R Pressley, Alex McGill, Yuanyuan Bai, Hai Yu, Xi Chen, Shota Atsumi
Published: 202510.1016/j.ymben.2025.12.001
Abstract
Human milk oligosaccharides (HMOs), such as lacto-N-tetraose (LNT), play critical roles in infant health by shaping gut microbiota and modulating immune function. While LNT is already produced at industrial scales, efficient microbial routes to more…
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