Journal of molecular and cellular cardiology
Cyclic AMP-dependent regulation of ryanodine receptors in healthy and diseased hearts.
Mohit M Hulsurkar, Isabelle Ong, Joshua A Keefe, Issam H Abu-Taha, Dobromir Dobrev, Xander H T Wehrens
Published: 202510.1016/j.yjmcc.2025.11.013
Abstract
Cyclic adenosine monophosphate (cAMP) is a critical second messenger in cardiomyocytes, regulating essential cellular functions. Upon G-protein-coupled receptor stimulation, adenylyl cyclase (AC) synthesizes cAMP, which phosphodiesterase (PDE) enzyme…
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