Journal of molecular and cellular cardiologyAnimalsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsInsulin-Like Growth Factor IMiceTachycardia
IGF-1 promotes cell surface expression of HCN4 pacemaker channels contributing to tachycardia.
Nadine Erlenhardt, Franziska Wohlfarth, S Erfan Moussavi-Torshizi, Angela Koch, Tobias Strasdeit, Katharina Scherschel, Ehsan Amin, Max Anstötz, Christian Meyer, Nikolaj Klöcker
Published: 202610.1016/j.yjmcc.2025.10.015
Abstract
Insulin-like growth factor 1 (IGF-1) controls cardiac growth, metabolism, and contractility. Whereas IGF-1 deficiency is associated with cardiovascular risk, the activation of its signal transduction may be cardioprotective after acute myocardial inf…
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