Gynecologic oncology
Substratification of mismatch repair deficient endometrial cancers based on mechanism of MMR loss can provide prognostic and predictive refinement.
Amy Jamieson, Sila Rogan, Allen W Zhang, Spencer D Martin, Samuel Leung, Derek Chiu, Kathryn McRae, Sarah J Mah, Stefan Kommoss, Aline Talhouk, David G Huntsman, C Blake Gilks, Jessica N McAlpine
Published: 202610.1016/j.ygyno.2026.01.233
Abstract
BACKGROUND: Mismatch repair deficient (MMRd) endometrial carcinomas (EC) encompass 25-30% of ECs. Identifying MMRd directs Lynch Syndrome testing and immune checkpoint inhibitor (ICI) therapy. Our aim was to characterize the clinicopathologic and mol…
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